TMED11 Conference

Shaping Future Healthcare with Clinical Research and Personalised Prescribing

Join us at the historic Guildhall, Derry-Londonderry for the 11th TMED Conference – a leading international event in translational medicine bringing together clinical researchers, academics, industry partners and healthcare innovators from across the UK and Europe.

Abstracts

Poster 1- Cardiac-senescent proteins differentiate paroxysmal from permanent atrial fibrillation

Authors: Smith A1, McLarnon T1, Peace A2, Watterson S1, Rai TS1

Poster 2- Extended Reality (XR)-supported exercise intervention in post-breast cancer surgery patients

Authors: Brennan, A¹., Blackburn, N²., Rankin, D¹., McCreadie, K¹., Charles, T³., Condell, J¹

Poster 3- Plasma proteomic biomarker discovery for depression and schizophrenia: a cross-cohort analysis with external validation

Authors: Alys Cowdy, Steven Watterson, Elaine Murray

Poster 4- Dose and time dependent modulation of endothelial redox balance and nitric oxide bioavailability by quercetin

Authors: A1 Isabella Fiandra. A2 Stephanie Whittam. A3 Andrew English

Poster 5- Developing Innovative Analytical Methods for research on Deprescribing: An overview of the DIAMOND research programme

Authors: Doherty, A. S.1, Essilini, A. 1, Gomez-Lemus, J. 1, Muddiman, R. 1, & Moriarty, F. 1

Poster 6- The computational design of peptide-based vaccine candidates for Lassa Fever

Authors: Anna Friel, A1., Gavin Markey, A1., Priyank Shukla, A1., David Gibson, A1

Poster 7- DNA Double Stranded Break Sequencing Following High Intensity Exercise

Authors: Aya M. Mohammed and Gareth W. Davison

Poster 8- The Northern Ireland Adult Inherited Neuropathy Cohort: Epidemiology, Molecular Diagnosis and Opportunities for Genomic Re-evaluation

Authors: Christy Kuriakose, A1, Nawab Ali A2, A3, Caoimhe McKenna A3, Sarah Mason A4, Gavin McCluskey A5, John McConville A4,A6, Grace McMacken A2,A4.

Poster 9- NLRP3 inflammasome related protein expression reflects chronic cardiovascular disease burden

Authors: Ciara Costello1*, Melody Chemaly 2, Aaron Peace 3, Steven Watterson1, Victoria McGilligan1.

Poster 10- Senescence Signatures Distinguish AKI Patients at Risk of Progression to Chronic Kidney Disease

Authors: Donya Ghazinader1 | Thomas McLarnon1 | Frank McCarroll2 | Steven Watterson1 | Taranjit Singh Rai1*

Poster 11- Intrathecal Tofersen for treatment of SOD1 Motor Neuron Disease in Northern Ireland

Authors: McCullagh M1, McKee J1, McVerry F1, McCarron M1, McCluskey G1

Poster 12- Investigating the novel albendazole-venetoclax drug combination for paediatric acute myeloid leukaemia

Authors: Seodhna M. Lynch1, Rachael Wilson2, Tríona Ní Chonghaile3, Alex Thompson4,5, Ken Mills4, Ross Levine6, Kyle B. Matchett1

Poster 13- Drug-induced CYP2D6 phenoconversion among individuals with a psychiatric disorder: prevalence and association with psychological distress

Authors: Mason, E.R.¹, Ali, M.Y.¹, Burns, R.M.²·³, Shukla, P.¹, Courtenay, A.⁴, Gibson, D.S.¹, Murray, E.K.¹, Kelly, C.¹

Poster 14- Clozapine-associated oral pathobiont colonisation in patients with treatment resistant schizophrenia.

Authors: Francesca McDonagh 1, Elaine K. Murray 2, Brian Hallahan 3, Georgios Miliotis 1,4

Poster 15- The role of the nlrp3 inflammasome in patients with alzheimer’s disease and mild cognitive impairment: findings from plasma proteomic analyses in the uk biobank, adni and a northern irish cohort

Authors: McNaugher, G., McClean, P., Gibson, D., Murray, E. and McGilligan, V.

Poster 16- From Sequencing to Survival: Molecular Stratification of Colorectal Cancer in Routine Practice

Authors: Hebaallah Elsandoby1, Praveen Baskar1, Oliver Benfield1, Nitesh Dulal1, Mariam Saleh1,2, Zainab Nisar1, Raafat A.Malek1,2

Poster 17- Could ABO blood group and PIV serve as prognostic markers to support personalised treatment in advanced NSCLC? A 5-year real-world study from Northern Ireland

Authors: Hebaallah Elsandoby1, Ryan Hacket 2, Claire O’Neil 2, Sara Hassan Shams Eldin1, Mariam A.Saleh1, Praveen Baskar1, Ruba Hamed2, Raafat A. Malek1

Poster 18- BloodTrackR Usability and Concordance Study (BUCS): Evaluating a Smart Home-Based Blood Collection Platform for Remote Monitoring in Rheumatoid Arthritis

Authors: Jency R. Rajan, 1., David S. Gibson, 1.

Poster 19- Computation design of peptide-based vaccine candidates for protoparvoviruses

Authors: A1. Jenica Aparicio

Poster 20- Localised Low-Dose Radiotherapy for Indolent B-Cell Lymphomas: Evaluating Service Devolution, Timelines, and Clinical Outcomes

Jithin Kuriakose *, A1., Lorna Collins *, A1., Haley Starr *, A1., Raafat Abdel-Malek, A2. Affiliations: A1 - School of Medicine, University of Ulster, Derry-Londonderry, United Kingdom. A2 - North West Cancer Centre, Altnagelvin Hospital, Londonderry, United Kingdom.

Poster 21- Co-development of a Clinician- and Patient-Centred REDCap Tool for PGx Implementation

Authors: Jonathon McLaughlin 1, Teerath Kumar Menghwar 2, David Gibson 1, Elaine Murray 1, Micheal McCann 2, Catriona Kelly 1, Laura Grimley 1, Annie Sellers 1

Poster 22- Investigating Mental Health Burden and the Oral Microbiome in ADHD

Authors: Laura McGrogan, A1., Margaret McLafferty, B2., Elaine K. Murray, A1.

Poster 23- NLRP3 inflammasome-related proteins are differentially expressed in depression: evidence from UK biobank

Authors: Leah McColgan, Elaine K. Murray, Catriona Kelly, Sophie Coyle, Steven Watterson, Victoria McGilligan

Poster 24- Exploring the research experiences and views of healthcare professionals in the Belfast Trust

Authors: A1.Lia McNamee (1), A2.Laura Cushley (2), A3.Jonathan Jackson (1)

Poster 25- An Autonomous Multi-Agent AI Framework for Pan-European Cardiovascular Disease Mortality Surveillance

Authors: Mohseni, M1., Rai, TS1., Wang, H2., Zheng, H2., Watterson, S1

Poster 26- Plasma Proteomics Identifies Replicated Inflammatory Signatures Associated with Glaucoma Across Multiple Independent Cohorts

Authors: Mia Church1, Sophie Coyle1, Colin Willoughby2, James Church3, Colm O’Brien4, Sarah-Louise McDaid-McCloskey1, Fionn O’Leary4, Pirro Hysi5, Ajda Pristovec5, Steven Watterson1, Sarah Atkinson2, Meredith Gregory-Ksander5, Victoria McGilligan1

Poster 27- Alpha-Melanocyte Stimulating Hormone improves glucose control in humans with type-1 diabetes

Authors: Muzamil Hussain1, Brett Johnson1,2, Neil Tanday1, Chris McGee1, Grace Curry1, Patrick Swan1, Ruth Price1, Carel W. le Roux3, Michael Cowley4 & Alexander Dimitri Miras1,2

Poster 28- Role of bioinformatics and artificial intelligence in accelerating peptide-based vaccine discovery

Authors: Nomathamsanqa Tholo1, Gavin Markey1, Ruairidh Harrigan1, Preeti Pandey2, Bodhayan Prasad3, Ram Shankar Barai4, David Samuel Gibson1, Priyank Shukla1

Poster 29- Real-world outcomes of consolidation durvalumab after chemoradiotherapy in stage III NSCLC: prognostic impact of pan-immune inflammatory value

Authors: Omar Elkhouly, Praveen Baskar, Keerthi Vivekanandan, Saranya Vivekanandan, Raafat Malek

Poster 30- Developing an Integrated Data Harmonisation Framework for Cross-Border Digital Health Research: Early Experience from the PEACETIME Project

Authors: A1 - Owais A. Malik, B1 - Michael McCann

Poster 31- Developing a REDCap data capture pathway to support personalised prescribing and medicines optimisation in primary care: the iMPROVE project

Authors: Kumar, T.¹, McLaughlin, J.², Murray, E.², Gibson, D.², McCann, M.¹

Poster 32- Senescence Biomarkers Independently Predict Disease-Related Mortality in Chronic Kidney Disease

Authors: 1 Thomas McLarnon, 1 Donya Ghazinader, 2 Frank McCarroll, 2 Jack Duncan, 2 Laura Lennox, 1 Steven Watterson, 1 Taranjit Singh Rai

Poster 33- A machine learning approach to predicting lung cancer risk using clinical and geospatial variables

Authors: Valentina Gogulancea1, Aileen Lonie2, Adrian Moore2, Adrián Otamendi Laspiur3, Eduardo Alonso3, Alba Garin-Muga3,4, Julien Guiot5, Astrid Paulus5, Benoit Ernst5, Marjorie Gangolf6, Jon Eneko Idoyaga Uribarrena7, Eunate Arana Arri7, Francisco Núñez-Benjumea8, Miguel Giraldez-Álvarez8, Frank Guijarro Masero9, Sara Alvarez Munoz9, Jonathan Wallace10, Michaela Black1, Debbie Rankin1

Abstract list

TMED11 Conference

Shaping Future Healthcare with Clinical Research and Personalised Prescribing

Abstracts